Red Reishi Helps Hamsters Lower Cholesterol!
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Red Reishi Useful For Lowering Cholesterol?
1Nestlé Research Center, Lausanne 26, 1000, Switzerland. [email protected]
INTRODUCTION:
There has been renewed interest in mushroom medicinal properties. We studied cholesterol lowering properties of Ganoderma lucidum/red reishi (Gl), a renowned medicinal species.
RESULTS:
Organic fractions containing oxygenated lanosterol derivatives inhibited cholesterol synthesis in T9A4 hepatocytes. In hamsters, 5% Gl did not effect LDL; but decreased total cholesterol (TC) 9.8%, and HDL 11.2%. Gl (2.5 and 5%) had effects on several fecal neutral sterols and bile acids. Both Gl doses reduced hepatic microsomal ex-vivo HMG-CoA reductase activity. In minipigs, 2.5 Gl decreased TC, LDL- and HDL cholesterol 20, 27, and 18%, respectively (P < 0.05); increased fecal cholestanol and coprostanol; and decreased cholate.
CONCLUSIONS:
Overall, Gl has potential to reduce LDL cholesterol in vivo through various mechanisms. Next steps are to: fully characterize bioactive components in lipid soluble/insoluble fractions; evaluate bioactivity of isolated fractions; and examine human cholesterol lowering properties. Innovative new cholesterol-lowering foods and medicines containing Gl are envisioned.
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Tags: cholesterol, diet, fungi, ganorderma lucidum, hamster, hamsters, health, LDL, ling zhi, medicinal mushrooms, nestle study, red reishi, reishi study
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